Kim et al., (2020) found that HAVCR2 (TIM-3) plays specific intracellular and intercellular immunoregulatory roles in the TME of gliomas. Studies have shown that the HLA level is positively related with development of gliomas (Machulla et al., 2001). In this study, risk score was positively correlated with expression of immune checkpoint molecules and HLA complex. This evidence concerns the gene HAVCR2 and central nervous system cancer.