The results showed that in the TCGA dataset, the risk score was elevated in the IDH wild-type (WT), 1p/19q non-codeletion subtype, MGMT promoter unmethylated subtype, older patients, and high-grade glioma (p < 0.05); we validated these results in the CGGA dataset (Figure 6A; Supplementary Figure S5A). The gene discussed is MGMT; the disease is central nervous system cancer.