ACE2 and hemorrhagic stroke: According to previous articles (Spence et al., 2020; Wang et al., 2020), the plausible mechanisms of hemorrhagic strokes were the increased affinity of SARS-COV-2 to angiotensin-converting enzyme 2 (ACE2) receptors, which were mainly expressed in endothelial and arterial smooth muscle in brain tissues, allowing SARS-COV-2 to invade and cause damages to cerebral blood vessels, and finally leading to blood vessels rupturing.