MLKL and cancer: Subsequent in vitro experiments demonstrated that overexpression of RIP3 significantly stunted the proliferation of cancer cells; similar to the above reports, Ertao et al. (2016), Sun et al. (2019) found that the down-regulation of MLKL was significantly associated with reduced OS in gastric cancer (GC) patients, implying that MLKL expression may be an independent predictive indicator for GC patients.