Our study identified six potential necroptosis genes of prognostic value, among which the ACTB-FSTL4 antagonistic relationship might be related to the mode of action of necroptosis in DLBCL, for patients with high expression of ACTB possessed a better prognosis, while upregulation of FSTL4 tended to indicate a poor prognosis. The gene discussed is ACTB; the disease is diffuse large B-cell lymphoma.