Höckendorf U et al. found in acute myeloid leukemia mice that cell death induced by RIPK3 and the release of interleukin-1b (IL-1b) which was mediated by inflammasome, limited myeloid leukemogenesis via eliminating transformed cells and promoting differentiation of leukemia-initiating cells (Höckendorf et al., 2016); furthermore in the clinical 125 observed patients in chronic lymphocytic leukemia (CLL) found that the group of patients with low expression of the CYLD, which is a key mediator molecule in the necroptosis process, had a worse prognosis. Here, RIPK3 is linked to B-cell chronic lymphocytic leukemia.