We also noted in particular that in cluster 1 high levels of NK cell infiltration, and numerous experiments demonstrated that NK cells functioned effectively in fighting transformed and malignant cells (Hodgins et al., 2019), and in a clinical study by low NK cell counts could contributed to impaired R-CHOP response and increased risk of cancer recurrence Zare et al. (2020). This evidence concerns the gene DDIT3 and cancer.