Subsequent in vitro experiments demonstrated that overexpression of RIP3 significantly stunted the proliferation of cancer cells; similar to the above reports, Ertao et al. (2016), Sun et al. (2019) found that the down-regulation of MLKL was significantly associated with reduced OS in gastric cancer (GC) patients, implying that MLKL expression may be an independent predictive indicator for GC patients. This evidence concerns the gene MLKL and gastric cancer.