Conversely, genetic variations near IRS-1 (such as the major allele of rs2972146 (Teslovich et al., 2010), rs2943641 (Rung et al., 2009), rs2943634 (Samani et al., 2007)), resulting in decreased IRS-1 expression, are associated with impaired metabolic profile, such as an increased visceral to subcutaneous fat ratio, insulin resistance, hyperlipidaemia, decreased adiponectin levels, thus enhancing the risk of diabetes and CAD (Samani et al., 2007; Rung et al., 2009). The gene discussed is IRS1; the disease is hyperlipidemia.