• PNPLA3 rs738409 G allele encodes PNPLA3 protein (I148M) which reduces hydrolyse activity, leading to impaired intrahepatic TG breakdown, hampers VLDL particle production and secretion.144 Therefore, PNPLA3 minor allele correlated with reduction in plasma lipids145 → reducing risk of CAD. This evidence concerns the gene PNPLA3 and coronary artery disorder.