Reports also highlight differences in the lipid profiles between “metabolic NAFLD” and “PNPLA3 NAFLD”, with higher levels of polyunsaturated TGs in the genetic “PNPLA3 NAFLD” compared to the metabolic-related NAFLD, thus proposing that these two entities may be distinct drivers of fatty liver diseases. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.