Conversely, genetic variations near IRS-1 (such as the major allele of rs2972146 (Teslovich et al., 2010), rs2943641 (Rung et al., 2009), rs2943634 (Samani et al., 2007)), resulting in decreased IRS-1 expression, are associated with impaired metabolic profile, such as an increased visceral to subcutaneous fat ratio, insulin resistance, hyperlipidaemia, decreased adiponectin levels, thus enhancing the risk of diabetes and CAD (Samani et al., 2007; Rung et al., 2009). This evidence concerns the gene IRS1 and diabetes mellitus.