It has been proposed that the true function of PNPLA3 is in lipid droplet remodelling and VLDL production (Trépo et al., 2016), and PNPLA3 variants are associated with lower plasma lipid concentrations for both triacylglycerols and LDL cholesterol (Liu et al., 2017), explaining the negative correlation between the polymorphism and CAD. The gene discussed is PNPLA3; the disease is coronary artery disorder.