At the gene level annotation, by selecting high impact variant at the SNV/Indels level filter above the gene annotation table, users obtain four genes with significant functional alterations: ARID1A, ZFHX3, GADL1, and ARID2. Based on the results, ARID1A has 2 related pathways, 70 related cancer cohorts, 55 related publications, and 7 related drug interactions. Here, ZFHX3 is linked to cancer.