Alteration of SCN1A (sodium voltage-gated channel alpha subunit 1) are associated with Dravet Syndrome (OMIM #607208, Supplementary Table S1), a Mendelian disorder characterized by drug-resistant epilepsy with early-onset seizures (usually during the first year of life) after apparently normal development, and usually induced by fever, at least initially (Dravet, 1978). This evidence concerns the gene SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.