SCN1A and epilepsy: Alteration of SCN1A (sodium voltage-gated channel alpha subunit 1) are associated with Dravet Syndrome (OMIM #607208, Supplementary Table S1), a Mendelian disorder characterized by drug-resistant epilepsy with early-onset seizures (usually during the first year of life) after apparently normal development, and usually induced by fever, at least initially (Dravet, 1978).