CYP1A1 and esophageal cancer: The majority of the studies including the present study suggest that esophageal cancer can be associated with mutations of CYP1A1, CYPA1A MspI T/C, CYP1A1 A2455G, CYP1A1T3801C A2455G, and a threefold increased risk for esophageal malignancy observed in patients with CYP2C19PM phenotype variant [36].