TNF and familial Mediterranean fever: It is a pediatric syndrome that affects both sexes, with slightly more male predominance, and has no predilection for any particular ethnic or racial group [1-3]. Considering the molecular mechanisms, these autoinflammatory diseases can be categorized into Inflammasomopathies or IL-1 β-activation syndromes including familial Mediterranean fever (FMF), cryopyrin-associated periodic syndromes (CAPS), and mevalonate kinase deficiency (MKD), and protein folding disorders such as tumor necrosis factor (TNF) and receptor-associated periodic fever syndrome (TRAPS) [4,5,6].