In the Kell blood group system, Kpb antigen was found to be significantly high in beta-thalassemia in 308 (87.0%) of the patients, followed by iron deficiency anemia in 44 (91.6%) patients and aplastic anemia in 27 (6.4%) of the patients while in Duffy blood group system, Fya and Fyb antigens were detected significantly high in beta-thalassemia in 256 (72.3%) and 182 (51.4%) of the patients respectively with a statistically significant relationship (p-value=0.001). The gene discussed is FYB1; the disease is anemia.