In lung tissues of early COPD patients, it was found that Th17 skew-related intracellular signaling is increasingly mediated by transcription factors such as signal transducer and activator of transcription (STAT3) and retinoid-related orphan nuclear receptor γt (ROR-γt), and ROR-γt gene expression in lung tissue is consistent with IL-6 levels [9]. This evidence concerns the gene IL6 and chronic obstructive pulmonary disease.