The progression of HCC involves many factors, including environmental exposure, somatic mutations, and transcriptional or epigenetic variations [12], among which, genetic mutations of several key genes (e.g., TP53, catenin beta 1 (CTNNB1), and telomerase reverse transcriptase (TERT)) have considerable relevance to the carcinogenesis and prognosis of HCC [13–15]. Here, CTNNB1 is linked to hepatocellular carcinoma.