ARIDs mutations, 127 CpGs methylation in all ARIDs, and the expression levels of ARID1A/B, ARID2, ARID3A/B/C, ARID5B, KDM5A/B/C/D, and JARID2 were related to the prognosis of patients with HCC. Here, ARID5B is linked to hepatocellular carcinoma.