The expression levels of ARID1A, ARID2, ARID3A, ARID3B, ARID4B, ARID5B, KDM5A, KDM5B, KDM5D, and JARID2 were upregulated, and expression levels of ARID1B, ARID4A, ARID4B, and KDM5D were downregulated in all types of liver cancers (including hepatocellular adenoma, liver cell dysplasia, HCC, and cirrhosis). The gene discussed is KDM5D; the disease is liver cancer.