Furthermore, based on the TCGA dataset, mRNA expression of ARID1A, ARID1B, ARID2, ARID3A, ARID3B, ARID4B, KDM5A, KDM5B, KDM5C, KDM5D, and JARID2 was remarkably overexpressed, and ARID3C and ARID4A were underexpressed in HCC (Figure 2). The gene discussed is KDM5B; the disease is hepatocellular carcinoma.