(I) Stevia glycoside inhibits hydroxymethylglutaryl CoA reductase (HMGCR), thereby reducing low-density lipoprotein (LDL) levels in blood and preventing atherosclerosis (134); (II) By fed 5% psicose to diabetic mice models and compared their outcomes to those fed with sucrose. The gene discussed is HMGCR; the disease is atherosclerosis.