Among them, there were eight signaling pathways, including PI3K-Akt signaling pathway, C-type lectin receptor signaling pathway, Cellular senescence, FoxO signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Neurotrophin signaling pathway, EGFR tyrosine kinase inhibitor resistance and apoptosis. The gene discussed is CD274; the disease is cancer.