IFNG and Anxiety: In animal models, inflammatory conditions caused by the peripheral administration of lipopolysaccharide (LPS), which causes systemic inflammation through increased production of interferon-gamma (IFN-γ), IL-6, and interleukin-1 beta (IL-1β), have been shown to lead to both depressive-like and anxiety-like behaviors (Godbout et al., 2005; Huang et al., 2008; Jangra et al., 2014).