Pre-clinical data in multiple solid tumors suggest a therapeutic role for EZH2 inhibitors (Wee et al., 2014; Keilhack and Smith, 2015), whereas in clinical trials, including patients with non-Hodgkin’s lymphoma (NHL) and solid tumors, only NHL patients responded clinically to the treatment (Ribrag et al., 2015). This evidence concerns the gene EZH2 and non-Hodgkin lymphoma.