The results of this study suggested that mdivi-1 intervention reduced mitochondrial ROS and serum MDA levels and increased serum SOD content in gastric antrum tissue compared with the model group, and the morphological structure of ICC mitochondria was clearer and the nuclear membrane was more intact under TEM, suggesting that mdivi-1 intervention could reduce mitochondrial oxidative stress in FD rats. Here, SOD1 is linked to Fabry disease.