Several experiments have been carried out following this direction: for instance, in long QT syndrome, the use of terfenadine carboxylate (fexofenadine), which differs from terfenadine by only a single carboxylic group, induced the recovery of trafficking defective HERG mutants with lower potency for the HERG block (Rajamani et al., 2002). Here, KCNH2 is linked to Prolonged QT interval.