As early as 2014, Novelli and Neri’s team demonstrated that the BALF of patients with PF, which contained procoagulant microparticles and tissue factor, could activate coagulation factor X to Xa and potentially contribute to the pathogenesis of PF by regulating fibroblast growth and differentiation (Novelli et al., 2014). The gene discussed is F10; the disease is pemphigus foliaceus.