MSCs derived from bone marrow (BM), adipose tissue (AD), and placenta confirmed that exosomes from MSCs could reduce inflammation by regulating related signaling pathways and polarization, and could also reduce collagen deposition in bleomycin- (Mansouri et al., 2019; Dinh et al., 2020; Wan et al., 2020), silica- (Choi et al., 2014; Phinney et al., 2015; Bandeira et al., 2018; Dinh et al., 2020), PM2.5- (Gao et al., 2020), and radiation- (Lei et al., 2020) induced PF models and TGF-β stimulated myofibroblasts (Shentu et al., 2017). The gene discussed is TGFB1; the disease is pemphigus foliaceus.