NPC1L1 has an impact on colorectal cancer patients’ overall survival, with patients in the NPC1L1 high-expression group having a worse OS than NPC1L1 patients, according to a KM analysis of the NPC1L1 low-expression group and the NPC1L1 high-expression group on OS (Figure 4). The gene discussed is NPC1L1; the disease is colorectal cancer.