On the other hand, DHZC, a representative one of PYXZ, can reduce serum levels of transforming growth factor β1 and tumor necrosis factor-α by downregulating protein levels of phosphatidylinositol 3-kinase (PI3K) and phosphorylated Akt in the rat model with liver fibrosis, and in vitro experiment further confirmed that it was capable of suppressing HSC proliferation via downregulating PI3K/Akt (Gong et al., 2020). This evidence concerns the gene AKT1 and Hepatic fibrosis.