oleandrin, a carcinogenic glycoside, kills cancer cells in the U2OS and SaOS-2 lines by inducing cell apoptosis through the ROS Generation as well as the damage of Mitochondrial membrane potential, which discharges hydrolytic Enzymes into the cytosol and regulates the proteins (decreases the Bcl-2 level and increase Bax) along with caspases (caspases 9 and 8 and -3 (Liu et al., 2004). This evidence concerns the gene BCL2 and cancer.