Eight clinical symptoms were closely associated with metabolites involved in choline metabolism in cancer, arginine biosynthesis, D-arginine and D-ornithine metabolism, glycerophospholipid metabolism, valine, leucine and isoleucine biosynthesis, sphingolipid metabolism, ether lipid metabolism, central carbon metabolism in cancer, arginine and proline metabolism and mTOR signaling pathway. This evidence concerns the gene MTOR and cancer.