Further, the relative mRNA expression of PFKFB4 in SKCM (Skin Cutaneous Melanoma) data from TCGA (The Cancer Genome Atlas) combined with Skin data from GTEx (Genotype-Tissue Expression) was significantly higher (p < 2.22e-16) in tumor (469 samples) than that of normal (557 samples) (Figure 3B). The gene discussed is PFKFB4; the disease is cancer.