BDH1 and cardiomyopathy: On the other hand, our quantitative proteomics results showed that DS decoction significantly upregulated the expression of MYH7, which as mentioned earlier plays a vital role in development of cardiomyopathy, and downregulated the expression of BDH1, which acts as an actin filament binding protein and is involved in cardiac diseases (Brahma et al., 2020).