TPM1 and dilated cardiomyopathy: We can see that the myosins, for example, MYH6 and MYH7, and tropomyosins (TPM1 and TPM2) are deeply implicated in the dilated cardiomyopathy signaling pathway (Supplementary Figure S8) and the calcium signaling pathway (Supplementary Figure S9), of which both play a crucial role in the contractility of cardiac cell and the remodeling of the myocardium (Figure 8).