MYH14 and familial dilated cardiomyopathy: For example, danicamtiv, a promising cardiac myosin activator, also known as MYK-491, was reported to selectively promote cardiac actomyosin activity by increasing myosin head availability and phosphate release rates (Shen et al., 2021), reversing respective contractile disordered in engineered heart tissue models of HCM and DCM (Halder et al., 2021).