The activation of the signal transducer and activator of transcription 3 (STAT3) can rapidly upregulate the expression of some cellular proteins, including NPPA and MYH7 (Figure 7), which were significantly upregulated in rats with ISO-iCM (vide supra) and in the patients with DCM (Chan et al., 2020; Toepfer et al., 2020). This evidence concerns the gene NPPA and familial dilated cardiomyopathy.