Combined with previous studies that SB had stronger β-secretion in vitro and cholinesterase inhibitory activity (Choi et al., 2011; Liu et al., 2020; Tian et al., 2020), so we selected SB as the present research object to preliminarily explore its effect and mechanism of improving scopolamine-induced cognitive impairment. This evidence concerns the gene BCHE and Cognitive impairment.