EDN1 and Alzheimer disease: IL6 and ERBB2 can participate in the inflammatory response during AD (Papassotiropoulos et al., 2001; Chaudhury et al., 2003); EIF4EBP1 can regulate cell proliferation (Pause et al., 1994); ENO2 can have neurotrophic and neuroprotective effects (Takano et al., 2016); the levels of neurotrophic factors EDN1 and HIF1A in the cerebral cortex are upregulated, while VEGFA levels were down-regulated during AD, leading to dysregulation of vascular homeostasis and angiogenesis (Hibbs et al., 2021; Tsartsalis et al., 2021).