In addition, the following three genes (GSMDA, PYCARD, and VDR) that were previously identified as possible executors of pyroptosis and usually exhibited tumor-suppressive effects (Ding et al., 2016; Šutić et al., 2019; Ling et al., 2022) were also identified and included in the present PRG signature, further confirming its reliability. Here, VDR is linked to neoplasm.