Cortical dysfunction as the first neurological presentation, atypical for MS MRI lesions, as well as less frequent T2 OCBs and IgG index positivity along with higher rates of ANA titers ≥1/320 and anti-cardiolipin IgM and anti-β2GPI IgG positivity also characterized the CNS autoimmune group. The gene discussed is CD40LG; the disease is myeloid sarcoma.