This is consistent with the work by Yusof et al. suggesting that an IFN score based on quantitation of type I and II IFN inducible gene expression in peripheral blood along with the family history of autoimmunity was able to predict the conversion to SAD in ANA-positive individuals (El-Sherbiny et al., 2018; Md Yusof et al., 2018). Here, BTG3 is linked to Autoimmunity.