In line with previous reports, associations of type I IFN signature with female sex (Panchanathan et al., 2010; Gabriele et al., 2021), neutropenia (Hall et al., 2015; Mathian et al., 2019; Chasset et al., 2020) or high ANA titers (Wither et al., 2017) were detected. This evidence concerns the gene BTG3 and neutropenia.