IFNA1 and systemic lupus erythematosus: For instance, activation of type I interferon (IFN) pathway has been considered a central pathogenetic event in SADs in association with antibodies against ribonucleoproteins, disease activity indices, and renal involvement (Baechler et al., 2003; Kirou et al., 2005; Weckerle et al., 2011; Tsokos et al., 2016; Ronnblom and Leonard, 2019; Postal et al., 2020; Idborg and Oke, 2021), with type I IFN receptor blockade being recently approved for lupus patients (Morand et al., 2020; Deeks, 2021).