Of note, lupus and primary SS were the prevailing SAD diagnoses detected in our cohort, compatible with previous observations (Delalande et al., 2004; Bertsias and Boumpas, 2010; Massara et al., 2010; Unterman et al., 2011; Borowoy et al., 2012; Schwartz et al., 2019) and anti-Ro/SSA were the predominant reactivity among patients with SAD. The gene discussed is TRIM21; the disease is systemic lupus erythematosus.