By detecting the changes in cell proliferation, cycle, migration, invasion, and apoptosis and the expression of related mRNAs and proteins, this study will explore the effects of liraglutide on the PI3K/Akt/mTOR signal pathway and CRC cell proliferation, cycle, migration, invasion, and apoptosis, and preliminarily explore its possible mechanisms of action so as to provide an experimental and theoretical basis for CRC, combined with targeted drug therapy. Here, PIK3CA is linked to colorectal carcinoma.