PIK3CA and colorectal carcinoma: In addition, hypoxia-inducible factor-1α acts as a downstream regulatory unit of mTORC1, and its regulation of protein level is affected not only by the environmental oxygen concentration but also by interfering with the expression of hypoxia-inducible factor-1α in the PI3K/Akt signaling pathway, affecting the proliferation activity of CRC cells, thereby reducing the drug resistance of CRC cells (Deng et al., 2021), which further proves the necessity of in-depth research on PI3K/Akt/mTOR signaling pathway inhibitors.