Based on the aforementioned points, the effects of GLP-1 receptor agonists on tumor cells, and the effects of the PI3K/Akt/mTOR signaling pathway on cell biology, we boldly put forward the scientific hypothesis that GLP-1 receptor agonists can affect the proliferation, cycle, migration, invasion, and apoptosis of CRC cells by mediating PI3K/Akt/mTOR. Here, PIK3CA is linked to neoplasm.