Apelin-13 is also known to relieve the symptoms of anxiety in mice, and these anti-anxiety effects may be related to α, ß adrenergic, dopamine and 5-HT receptors since they were blocked by the administration of phenbenzamine, haloperidol, propranolol, and dimethylergometrine (Telegdy and Jászberényi, 2014). The gene discussed is APLN; the disease is Anxiety.