APOA5 and metabolic dysfunction-associated steatotic liver disease: In hepatocytes, apoA5 suppresses hydrolysis of triglycerides and facilitates the accumulation of lipid droplets, resulting in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), a disease characterized by excessive triglyceride-rich lipid droplets in hepatocytes (Zheng et al., 2013; Wu et al., 2016).