Furthermore, it was demonstrated that the over-expression of DCBLD2 is related to the increased invasive capacity of cancer cells and poor prognosis of patients with lung cancer (Koshikawa et al., 2002; Nagai et al., 2007), gastric cancer (Kim et al., 2008), colorectal cancer (He et al., 2020), and pancreatic cancer (Raman et al., 2018; Feng et al., 2020). Here, DCBLD2 is linked to cancer.