TWIST1 and neoplasm: For example, studies have reported that over-expression of EMT signal regulators (such as TWIST1 and MMPs) can promote immune infiltration in TME, which promotes tumor cell immune escape (Terry et al., 2017; Singh and CHAKRABARTI, 2019) Tumor immune escape is a major contributor to tumor malignancy, poor prognosis, and treatment failure (Whiteside, 2008; Tang et al., 2016; Wu and DAI, 2017).