In addition, phenotypic analysis of gene knockout mice, based on genetic screening, showed that knocking out DCBLD2 significantly affected lymphocyte-mediated tumor killing in tumor models (Freeman 2019 NK, Vredevoogd 2019 MART1, Kearney 2018 IgG, Manguso 2017 GVAX, Kearney 2018 T_PD1 and Patel 2017 2) (Figure 6D). Here, DCBLD2 is linked to neoplasm.