Experimentally, metastatic CL can be mimicked upon infection of the interferon gamma (IFN-γ)-deficient mice (Ifng−/−) with Lgy-bearing LRV1 (LgyLRV1+), which induces a severe metastatic phenotype (Hartley et al., 2016; Rossi et al., 2017). Here, IFNG is linked to infection.