The cytokine release syndrome (CRS) may lead to death among COVID-19-infected patients due to a substantial immune response characterized by abnormal cytokine production.” Several cytokines and chemokines participate in the “cytokine storm” in COVID-19 patients (Ragab et al., 2020), including IL-6, IL-1β, CXCL10, IL-2, IL-10, TNF-α and IFN-γ, but IL-6 plays an especially critical role, for its increased level in patients’ serum has been associated with respiratory failure, ARDS, and adverse clinical outcomes (Bhardwaj et al., 2022). This evidence concerns the gene IL1B and COVID-19.