TLR3 and infection: Paradoxically, this TLR3-mediated innate response exacerbates the disease as mice infected with LRV1-bearing Lgy (LgyLRV1+) develop higher lesions and display more parasite burden at the peak of infection when compared to their LRV1-negative counterparts (LgyLRV1-) (Ives et al., 2011).