INS and diabetes mellitus: We can distinguish between the three types of diabetes mellitus: 1) Type 1, the pancreas non-generates insulin and accounts for 10% of people with diabetes, most are young adults (Bergenstal et al., 2018); 2) Type 2, with a low rate of insulin production or the body is without insulin produced by the pancreas, accounts for 90% of people with diabetes, the majority are middle-aged or elderly (Jermendy et al., 2021); and 3) gestational diabetes, which occurs during pregnant pregnancy, and both the mother and the child have the possibility of developing diabetes (Koivusalo et al., 2016).