HDAC1 is recruited to the CDH1 promoter in pancreatic cancer cells, resulting in deacetylation of histone 3 and 4 proteins in the nucleus and E-cadherin depletion, which aids in the epithelial-mesenchymal transition (EMT) (Von Burstin et al., 2009). This evidence concerns the gene CDH1 and familial pancreatic carcinoma.