Our prior investigations demonstrated that oncogenic MYC regulates transcription of polyamine metabolizing enzymes ornithine decarboxylase (ODC1), spermidine synthase (SRM), and spermine synthase (SMS) in TNBC, and that elevated intracellular polyamine levels induce expression of SAT1 (Pegg, 2013) resulting in elevated cancer cell biosynthesis and secretion of acetylated polyamines (Fahrmann et al., 2020). This evidence concerns the gene SMS and cancer.