Factors preceding admission significantly associated with the admission to PICU were age, OR 1.18 (95% CI: 1.1–1.3); hypotension or shock at admission, OR 21.1 (95% CI: 7.2–62.4); positive RT-PCR antigen test for COVID-19, OR 3.7 (95% CI: 1.5–9.3); CRP ≥ 7.4 (median in our population), OR 5.2 (95% CI: 1.9–13.8); elevated procalcitonin and ferritin (OR 4.0, 95% CI: 1.2–13.4 and OR 3.9, 1.3–11.7, respectively); lymphopenia, OR 4.3 (95% CI: 1.8–10.5) and hypoalbuminemia OR 4.5 (95% CI 1.4–14.9). The gene discussed is CRP; the disease is lymphopenia.