Significant levels of c-MET activated β-catenin [Y654-β-catenin, (152)] were found in the cytoplasm and nucleus of clinical HB samples with wild-type CTNNB1, suggesting that aberrant accumulation β-catenin in these cases was due to HGF/c-MET signaling, a mechanism which was validated in a wild-type CTNNB1 HB cell line after HGF stimulation (153). Here, HGF is linked to hemoglobin measurement.