CTNNB1 and hepatocellular carcinoma: Tao et al. identified a subset of human HCC cases (9–12.5% of analyzed samples) containing both c-MET overexpression and mutation of the β-catenin gene (CTNNB1), and showed that overexpression of c-MET on the background of mutant β-catenin led to the formation of HCC in transgenic mice (171).