TSC2 and tuberous sclerosis: Furthermore, IPSCs-derived neurons and forebrain organoids with LIS1 mutations exhibited proliferative defects, resembling also the zebrafish model (Iefremova et al., 2017); while the molecular mechanisms underlying focal dysplasia and tuberous sclerosis due to mutations in TSC1 and TSC2 have been studied in 2D and 3D cortical systems from human brain (Marinowic et al., 2017; Blair et al., 2018).