• kif2a KO zebrafish embryos (Partoens et al., 2021): microcephaly, reduced NPCs proliferation, increased apoptosis. Evidence of susceptibility to seizures and cognitive impairments• MO-mediated dync1h1 KD in zebrafish embryos and dync1h1mw20KO mutants (Insinna et al., 2010): defective morphogenesis of outer segment in photoreceptors, associated with cell polarity and organelle positioning defects. The gene discussed is DYNC1H1; the disease is Cognitive impairment.