FD-causing mTORpathiesTSC1 and TSC2 (LoF somatic mutations causing FD, #607341;RHEB (Zhao et al., 2019)MED16 (Zhao et al., 2019) AKT3 (Alcantara et al., 2017)PIK3CA (Jansen et al., 2015)PIK3R2 (associated with PMG) (Terrone et al., 2016)DEPDC5 (second-hit mosaic mutations in the gene cause FD, #604364)TS-causing mTORpathiesGermline biallelic LoF mutations causing TS, #613254, # 191100)OthersSLC35A2 (Bonduelle et al., 2021). The gene discussed is PIK3R2; the disease is Fabry disease.