• zebrafish embryos overexpressing ARF3 mutant proteins (Fasano et al., 2021): microcephaly, fragmented Golgi and reduced cell protrusions and migration in early embryonic stem cells• MO-mediated trappc6b KD in zebrafish embryos (Marin-Valencia et al., 2018): reduced head size, increased apoptosis in the brain, increased susceptibility to seizures and neuronal hyperexcitability• MO-mediated rab18 KD in zebrafish embryos (Bem et al., 2011): microcephaly and developmental delay, reduced eye size and, delayed retinal development with abnormal retinal lamination. The gene discussed is ARF3; the disease is microcephaly.