Upon subsequent weighted gene co-expression network analysis (WGCNA), protein-protein interaction (PPI) network construction, and LASSO-penalized multivariate cox regression analysis, four genes (E2F1, CDC20, TYMS, and NUP85) were selected to construct a ferroptosis-related gene prognostic index (FRGPI) to predict the DFS of PCa patients receiving radical prostatectomy. This evidence concerns the gene E2F1 and posterior cortical atrophy.