CASP1 and neoplasm: In addition, we confirmed the differential DEGs in LUAD, such as absent in melanoma 2 (AIM2), gasdermin B (GSDMB), gasdermin C (GSDMC), etc. And we found the expression of AIM2, GSDMB and GSDMC were higher in tumor group compared to normal group, while the expression of caspase 1 (CASP1), caspase 4 like pseudogene (CASP4LP), interleukin 18 receptor 1 (IL18R1), interleukin 1 beta (IL1B), interleukin 6 (IL6) and NLR family CARD domain containing 4 (NLRC4) were lower in tumor group than normal group (Figure 1C).