INS and type 2 diabetes mellitus: While providing background information on blood glucose homeostasis and insulin resistance to those less familiar with these concepts Section 2: (Pancreatic physiology), we will also highlight key ways circadian rhythms are disrupted and how they interact to increase the risk of obesity and T2DM (Figure 3) discussed in Section 3 (Circadian rhythms in the pancreas), 4 (Molecular circadian rhythms in the pancreas) and 5 (Modulation of circadian rhythm).