IGF2 and neoplasm: The possible reasons were as follows: firstly, we know cTACE causes hypoxia and glucose deprivation, but hypoxia can simultaneously induce transcriptional activation of the IGF-2 gene, leading to increased production of pro-IGF-2, which compromises the effect of tumor cell death (28); secondly, tumor cells can survive with the help of proton and lactate, which may lead to treatment failure (27).