The most significant pathways are shown in Figure 6B and Table 4, and the genes in module brown were enriched in aldosterone synthesis and secretion, Ras signaling pathway, Hedgehog signaling pathway, calcium signaling pathway, PI3K-Akt signaling pathway, GnRH secretion, proteoglycans in cancer, nucleocytoplasmic transport, viral life cycle–HIV-1, and melanoma. The gene discussed is AKT1; the disease is cancer.