Transcriptional analysis from patients with cancers revealed that the expression of THY1 was relevant to the activation of unfolded protein response (UPR), especially inositol-requiring enzyme 1α (IRE1α), one of the ER transmembrane proteins, suggesting a functional connections between THY1 and ER (36).Previous studies revealed that the up regulation of THY1 is responsible to alleviate interstitial pulmonary fibrosis via blockade of the WNT signaling pathway in acute interstitial pneumonia (37). Here, ERN1 is linked to cancer.