Few studies of RHBDF1, THY1, MXRA8,FKBP10, PGF, SPON1, COL4A2, TMPRSS3, QSOX1, AGPAT4, COL5A1, CERCAM and COL8A2 have been reported at present in the field of NAFLD. The gene discussed is SPON1; the disease is metabolic dysfunction-associated steatotic liver disease.