Regarding the INS rs689 SNP, we also found a different genotypic distribution among our patients, with a reduced frequency of the (T) minor allele in patients diagnosed with T1DM when compared with LADA or T2DM, though no significant difference was seen between LADA and T1DM patients with an onset of >30 years (see Table 4). This evidence concerns the gene INS and type 2 diabetes mellitus.