SIRT3 and Cognitive impairment: Inhibit mitochondrial stress and endoplasmic reticulum stress pathways, and protect hypoxia/reoxygenation-induced apoptosis in human kidney proximal tubular cells.Upregulate mitochondrial SIRT3 activity, and reverse liver mitochondrial dysfunction in high-fat-fed rats.Inhibit the ROCK pathway, increase mitochondrial membrane potential, reduce ROS levels, and improve the cognitive impairment caused by diabetic encephalopathy.