It has been reported that miR-146a can regulate key downstream adaptor molecules of TLR in sepsis by complementary pairing with the 3’UTR base sequence of TNF receptor-associated factor 6 (TRAF6) and IL-1 receptor-associated kinase 1 (IRAK1) genes, thereby inhibiting the activity of TLR signaling pathway and thus inhibiting NF- κB signaling pathway to exert inflammatory suppressive effects (65). This evidence concerns the gene TRAF6 and Sepsis.